Codeine

Codeine
Systematic (IUPAC) name
7,8-didehydro-4,5-epoxy- 3-methoxy-17-methylmorphinan-6-ol
Identifiers
CAS number	76-57-3
ATC code	R05DA04
PubChem	5284371
DrugBank	APRD00120
Chemical data
Formula	C18H21NO3
Mol. mass	299.364 g/mol
Pharmacokinetic data
Bioavailability	~90% Oral
Metabolism	?
Half life	2.5 - 3 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule I(CA) Class B(UK) Schedule II(US)
Routes	oral, intra-rectally, SC, IM

Codeine (INN) or methylmorphine is an opiate used for its analgesic, antitussive and antidiarrheal properties. It is marketed as the salts codeine sulfate and codeine phosphate. Codeine hydrochloride is more commonly marketed in continental Europe and other regions.

Codeine is an alkaloid found in opium in concentrations ranging from 0.3 to 3.0 percent. While codeine can be extracted from opium, most codeine is synthesized from morphine through the process of O-methylation.

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